Persistent
or recurring
CRSwNP despite
long-term INCS†
Having received >1
course of SCS‡
in the preceding
2 years
Previous sinonasal
surgery§
Contraindication
to SCS
and/or surgery
Unwilling
to undergo
surgery
Persistent
or recurring
CRSwNP despite
long-term INCS†
Having received >1
course of SCS‡
in the preceding
2 years
Previous sinonasal
surgery§
Contraindication
to SCS
and/or surgery
Unwilling
to undergo
surgery
Nasal
congestion score
(0-3) ≥2 points
Loss of smell score
(0-3) ≥2 points
Sino-Nasal
Outcome Test-22
(0-110) ≥35 points
Total symptom
visual analog scale
≥5 out of 10 cm
Nasal
congestion score
(0-3) ≥2 points
Loss of smell score
(0-3) ≥2 points
Sino-Nasal
Outcome Test-22
(0-110) ≥35 points
Total symptom
visual analog scale
≥5 out of 10 cm
Main complaint:
smell loss OR nasal congestion
Coexisting type 2 disease:
Asthma, NSAID-ERD
Endoscopy:
polyps, eosinophilic mucin
Lab:
elevated IgE, eosinophilia
SOC responsiveness:
Improved smell and decreased
congestion with systemic steroids
Main complaint:
discharge/facial pain
Endoscopy:
purulence
Lab:
normal IgE, no eosinophilia
SOC responsiveness:
Minimal response to INCS
and antibiotics
Main complaint:
smell loss OR nasal congestion
Coexisting type 2 disease:
Asthma, NSAID-ERD
Endoscopy:
polyps, eosinophilic mucin
Lab:
elevated IgE, eosinophilia
SOC responsiveness:
Improved smell and decreased
congestion with systemic steroids
Main complaint:
discharge/facial pain
Endoscopy:
purulence
Lab:
normal IgE, no eosinophilia
SOC responsiveness:
Minimal response to INCS
and antibiotics
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