Patient-reported
lack of
disease control
VAS:
overall symptom
severity
VAS:
nasal obstruction
VAS:
loss of smell
Patient-reported
lack of
disease control
VAS:
overall symptom
severity*
VAS:
nasal obstruction*
VAS:
loss of smell*
Nasal congestion score
(0-3) ≥2 points
Loss of smell score
(0-3) ≥2 points
Sino-Nasal
Outcome Test-22
(0-110) ≥35 points
Total symptom
visual analog scale
≥5 out of 10 cm
Nasal congestion score
(0-3) ≥2 points
Loss of smell score
(0-3) ≥2 points
Sino-Nasal
Outcome Test-22
(0-110) ≥35 points
Total symptom
visual analog scale
≥5 out of 10 cm
Main complaint:
smell loss OR nasal congestion
Coexisting type 2 disease:
Asthma, NSAID-ERD
Endoscopy:
polyps, eosinophilic mucin
Lab:
elevated IgE, eosinophilia
SOC responsiveness:
Improved smell and decreased
congestion with systemic steroids
Main complaint:
discharge/facial pain
Comorbid disease:
less asthma, less NSAID-ERD, less atopy
Endoscopy:
purulence
Lab:
normal IgE, no eosinophilia
SOC responsiveness:
Minimal response to INCS
and antibiotics
Main complaint:
smell loss OR nasal congestion
Coexisting type 2 disease:
Asthma, NSAID-ERD
Endoscopy:
polyps, eosinophilic mucin
Lab:
elevated IgE, eosinophilia
SOC responsiveness:
Improved smell and decreased
congestion with systemic steroids
Main complaint:
discharge/facial pain
Comorbid disease:
less asthma, less NSAID-ERD, less atopy
Endoscopy:
purulence
Lab:
normal IgE, no eosinophilia
SOC responsiveness:
Minimal response to INCS
and antibiotics
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