Criteria for Assessing Response to Selected EoE Treatment
2017 UEG/EAACI/
ESPGHAN/EUREOS
and 2020 AGA/JTF Criteria for Assessing Response to EoE Treatment1,2
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Histology
The only currently available quantitative threshold of adequate therapeutic response is defined as <15 eos/hpf in esophageal mucosa1,2
Additional prospective, long-term studies are needed to confirm that reduction in esophageal eosinophilia prevents progressive disease remodeling2
Symptoms
Symptom assessment can be challenging due to use of non-validated instruments and behavioral adaptations that mask symptoms1,2
Symptoms do not correlate accurately with histologic disease activity1
EoE activity should not be assessed based only on symptoms1
Endoscopy
Endoscopic esophageal biopsies continue to be necessary to accurately monitor disease activity1
Follow-up endoscopy after a 6-to-12-week course of treatment has been suggested; however, the recommended frequency of EGD with biopsy during clinical follow-up may vary1,2