Diagnosis

Checklist for Diagnosing EoE

2018 AGREE Consensus
Diagnostic Criteria for EoE1

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Symptoms


Difficulty swallowing, chest pains, and comorbidity of food allergy to shellfish all reflect a clinical presentation suggestive of EoE

Endoscopic Assessment


Recent food impaction and EREFS total score of 5 out of 8 reflect upper endoscopic findings, which increase suspicion for EoE

Histologic Assessment


Esophageal eosinophilia of 40 eos/hpf is above the 15 eos/hpf threshold necessary to confirm EoE diagnosis

Exclusion of
Non-EoE Disorders


Lack of GERD excludes a common non-EoE disorder that may be present in patients with EoE

ALL of the Diagnostic Criteria are needed to confirm an EoE diagnosis, including requiring esophageal biopsies to assess eosinophil count1


Case based on hypothetical patient.
AGREE, A Working Group on PPI-REE; EoE, eosinophilic esophagitis; PPI-REE, proton pump inhibitor-responsive esophageal eosinophilia.

1. Dellon ES, et al. Gastroenterology.
2018;155(4):1022-1033.