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THE PATHOPHYSIOLOGY
OF AD IS MULTIFACTORIAL1,2,4
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AD IS ASSOCIATED WITH ELEVATED
TYPE 2 INFLAMMATION
FROM A YOUNG AGE3-5
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TYPE 2 INFLAMMATION MEDIATES
THE PATHOPHYSIOLOGY OF OTHER
ATOPIC/ALLERGIC DISEASES5,9
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AD IS THE MOST COMMON
INITIATING ATOPIC CONDITION5-7
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AD PROGRESSION CAN FOLLOW
MULTIPLE TRAJECTORIES1,5
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TARGETING TYPE 2
INFLAMMATION EARLY TO
PREVENT DISEASE PROGRESSION5,7
AD, atopic dermatitis.
1. Irvine AD, et al. Br J Dermatol. 2019;181(5):895-906.
2. Langan SM, et al. Lancet. 2020;396(10247):345-360.
3. Czarnowicki T, et al. J Allergy Clin Immunol. 2020;145(1):215-228.
4. Moniaga CS, et al. Diagnostics (Basel). 2021;11(11):2090.
5. Gabryszewski SJ, et al. Ann Allergy
Asthma Immunol. 2021;127(3):293-300.
6. Belgrave DC, et al. PLoS Med. 2014;11(10):e1001748.
7. Paller AS, et al. J Allergy Clin Immunol. 2019;143(1):46-55.
8. Weidinger S, et al. J Am Acad Dermatol. 2020:83(6)Supplement AB 29.
9. Ahern S, et al. Medicina (Kaunas). 2019;55(4):95.