CONTINUE
CONTINUE

Persistent
or recurring
CRSwNP despite
long-term INCS

Having received >1
course of SCS
in the preceding
2 years

Previous sinonasal
surgery§


Contraindication
to SCS
and/or surgery

Unwilling
to undergo
surgery

CONTINUE
CONTINUE

Persistent
or recurring
CRSwNP despite
long-term INCS

Having received >1
course of SCS
in the preceding
2 years

Previous sinonasal
surgery§


Contraindication
to SCS
and/or surgery

Unwilling
to undergo
surgery

CONTINUE

Nasal
congestion score
(0-3) ≥2 points

Loss of smell score
(0-3) ≥2 points

Sino-Nasal
Outcome Test-22
(0-110) ≥35 points

Total symptom
visual analog scale
≥5 out of 10 cm

CONTINUE
CONTINUE

Nasal
congestion score
(0-3) ≥2 points

Loss of smell score
(0-3) ≥2 points

Sino-Nasal
Outcome Test-22
(0-110) ≥35 points

Total symptom
visual analog scale
≥5 out of 10 cm

CONTINUE

Main complaint:
smell loss OR nasal congestion

Coexisting type 2 disease:
Asthma, NSAID-ERD

Endoscopy:
polyps, eosinophilic mucin

Lab:
elevated IgE, eosinophilia

SOC responsiveness:
Improved smell and decreased
congestion with systemic steroids

Main complaint:
discharge/facial pain

Endoscopy:
purulence

Lab:
normal IgE, no eosinophilia

SOC responsiveness:
Minimal response to INCS
and antibiotics

CONTINUE
CONTINUE

Main complaint:
smell loss OR nasal congestion

Coexisting type 2 disease:
Asthma, NSAID-ERD

Endoscopy:
polyps, eosinophilic mucin

Lab:
elevated IgE, eosinophilia

SOC responsiveness:
Improved smell and decreased
congestion with systemic steroids

Main complaint:
discharge/facial pain

Endoscopy:
purulence

Lab:
normal IgE, no eosinophilia

SOC responsiveness:
Minimal response to INCS
and antibiotics

CONTINUE
CONTINUE
START OVER

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