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1.1
1.1
as one of the symptoms
health-related quality of life.
with CRSwNP may indicate an increased risk for
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Patients with CRSwNP report the loss of smell and taste as one
of the SNOT-22 symptoms “most affecting” their
health.1
Furthermore, higher SNOT-22 scores may indicate an
increased risk for major depressive disorder.2
1.2
1.2
of being associated with type 2 inflammation in CRSwNP.
More associated
with
type 2 inflammation
Less associated
with
type 2 inflammation
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Patients with CRSwNP report the loss of smell and taste as one
of the SNOT-22 symptoms “most affecting” their
health.1
Furthermore, higher SNOT-22 scores may indicate an
increased risk for major depressive disorder.2
1.3
1.3
the first leg of your journey.
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Patients with CRSwNP and high levels of IL-13 in mucus show
increases in
olfactory dysfunction and sinonasal opacification
and are more likely to
have comorbid asthma.1-3
2.1
2.1
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In patients with CRSwNP, key type 2 cytokines
(IL-4, IL-13, and IL-5) can damage the epithelial barrier,
which can increase type 2 inflammation.
2.2
2.2
images to the endotype each is most likely to represent.
Type 1 inflammation
Type 2 inflammation
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Endotypes in CRS are associated with characteristic patterns
of
inflammation that can be seen on endoscopy, computed
tomography, and
histology.
2.3
2.3
edema is referred to as
olfactory cleft and impaired olfactory receptor neuron function
is referred to as
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Current research suggests that both conductive and
sensorineural
dysfunction contribute to smell loss in CRSwNP.
3.1
3.1
presence of
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Type 2 cytokines have been shown to be elevated in
olfactory cleft mucus of
patients with CRSwNP and inversely
correlated with smell identification
test
scores.
3.2
3.2
progenitor olfactory receptor neurons may be
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Current research suggests that both conductive and
sensorineural
dysfunction contribute to smell loss in CRSwNP.
