PN lesion clinical manifestations
Dyspigmentation is a common clinical manifestation of PN
Hyperpigmented rim1
Dyspigmentation is more
common in patients of color2,3
What process causes dyspigmentation?
Post-inflammatory responses
to scratching may lead to increased melanin
production and subsequent macrophage
phagocytosis causing hyperpigmentation2,4,5
Conversely, PN lesions may also heal
with post-inflammatory hypopigmentation6
How do PN clinical manifestations impact patients?
Body dysmorphic disorder is
6.5–fold
more prevalent in patients with PN7
45%
of patients note
anxiety
from physical appearance8
